Capsular contracture (CC) remains the most severe complication with silicone and saline breast implants, with an incidence ranging from 8 to 45 %.
Prevention and treatment measures for CC have been extensively discussed, but there is no agreement on a generally accepted therapeutic pathway
Loaded with a drug delivery feature to an existing breast implant can overcome the side effects of capsular contracture.
Inhibiting TGF-β alone may be ineffective for the treatment of fibrosis. However, we can expect improved effects with using Triamcinolone which is steroids generally inhibiting to the fibrosis pathway such as IL-13, IL-4R, and Stat 6.
Despite using an absorbable suture, some patients suffered from to foreign body reactions, acute pain, and infection at the surgical site
Oral administration or intravenous injection of the drug may result in drug delivery to unwanted sites, systemic side effects and the possibility of even a low bioavailability of a drug
The purpose of the present study is to discover the effectiveness of the newly developing porcine dermis with new drugs to prevent inhibition of fibrosis in the human body.
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